Elevated levels of a newly discovered molecule responsible for aging bones

As we age, our bodies increasingly produce a molecule that suppresses certain functions. As levels of this regulatory molecule rise, key signalling molecules that mediate bone growth decline. Older bodies suppress stem cell production on a molecular level, scientists report.

Researchers at the Medical College of Georgia at Augusta University have uncovered exciting evidence of systemic alterations that occur with age. Their work has revealed how bones weaken and deteriorate in the aging body. One molecule in particular – microRNA-141-3P – appears to accumulate in bone tissue over time. Scientists have found that elevated levels of microRNA-141-3P are associated with osteoporosis and assorted bone pathology. The problematic molecule inhibits the absorption of vitamin C by various bone cells. It prevents the skeleton from effectively utilizing vitamin C – slowly starving bones of a much needed nutrient. This systemic shift in nutrition limits the resources available for normal bone growth. Over time, aging bones weaken and osteoporosis can develop.

Researchers suspected that suppressing microRNA-141-3P could keep bones processing vitamin C and regenerating themselves for far longer than they would under normal aging conditions. Rodent test subjects were treated with a clinical grade inhibitor of microRNA-141-3P; the result was younger, stronger bones. Scientists theorize that a similar inhibiting medication could be used in human subjects to reverse and prevent bone deterioration. The research is compelling and paints an optimistic picture of beneficial anti-aging therapy.

Development and distribution of this drug are likely far in the future. Nevertheless, the research indicates that scientists may be able to keep bones younger, for longer. By regulating a single key component of a complex cellular network, bone aging may be prevented.

  1. Sudharsan Periyasamy-Thandavan, John Burke, Bharati Mendhe, Galina Kondrikova, Ravindra Kolhe, Monte Hunter, Carlos M Isales, Mark W Hamrick, William D Hill, Sadanand Fulzele. MicroRNA-141-3p negatively modulates SDF-1 expression in age dependent pathophysiology of human and murine bone marrow stromal cellsThe Journals of Gerontology: Series A, 2018; DOI: 10.1093/gerona/gly186

Gene mutation associated with hair loss and wrinkles

Researchers at the University of Alabama at Birmingham have been experimenting with mouse mitochondrial DNA. When they introduce a mutation into this gene sequence, mice develop hair loss and wrinkles. When this gene mutation is reversed and turned back on to normal, the mice returned to smooth skin and normal fur again. They also noticed that the mice seemed to have less energy and move more slowly. What is interesting is that these external signs of aging were able to be reversed.

Bhupendra Singh, Trenton R. Schoeb, Prachi Bajpai, Andrzej Slominski, Keshav K. Singh. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial functionCell Death & Disease, 2018; 9 (7) DOI: 10.1038/s41419-018-0765-9

Light Therapy for Skin

DaVinci Med Spa offers light therapy as a modality or as an add on to procedures. According to WebMD in an article titled Testing Potential Uses for Light Therapy, “For instance, when longer wavelength or visibly “red” light hits the skin, it nudges mitochondria (the cell’s powerhouses) to make energy more efficiently and boost production of healing anti-inflammatories or disease-fighting antioxidants.” 

Cortisone (triamcinolone) shots in arthritic knees or PRP

According to a recently published research paper by Timothy E. McAlindon, DM, MPH, et al, “Among patients with symptomatic knee osteoarthritis, intra-articular triamcinolone, compared with intra-articular saline, increased cartilage volume loss and had no effect on knee pain over 2 years.” This report was published in The Journal of the American Medical Association in May of 2017. 140 patients with symptomatic arthritis were entered into the study. Half got a cortisone shot every 3 months while the other half got saline (placebo) shots in their knee. Those that got cortisone shots resulted in significantly greater cartilage volume loss than did saline patients. In other words they lost cartilage with steroid shots and did no better as far as pain.

Dr AJ Cummings has been using Platelet Rich Plasma (PRP) instead of cortisone shots on his patients for years now. 

PRP for hip bursitis

Dr AJ Cummings, MD treating chronic hip bursitis with Platelet Rich Plasma (PRP) growth factors using ultrasound guidance.

Dr AJ Cummings using ultrasound guidence to deliver the regenerative healing properties of prp

Dr AJ Cummings using ultrasound guidence to deliver the regenerative healing properties of prp